胡洪波 国家“杰青”、“青千”，重庆国际免疫研究院副院长，四川大学生物治疗国家重点实验室研究员，四川大学华西医院免疫和血液研究中心主任，博士生导师。毕业于中国医学科学院/北京协和医学院，免疫学博士，在美国贝勒医学院、MD安德森癌症中心任博士后、讲师。2015年入职四川大学。主要从事免疫细胞发育和功能的分子机制研究。在国际权威学术期刊Nature，Immunity，Journal of Experimental Medicine，Cell Research等发表论文50余篇。承担科技部重点研发专项、国自然等国家级项目8项，累计经费超过2000万元。担任CellularMolecular Immunology, Journal for ImmunoTherapy of Cancer 和Cancer Letters编委。担任中国免疫学会青工委主委，中国病理生理学会实验血液学专委会委员，中国细胞生物学会青工委委员、细胞免疫分会委员。

近五年主要研究成果如下：(1) 在免疫细胞发育方面，解析了人类胸腺器官早期发生、发育的关键时间，人T细胞起源的异质性；解析了胚胎期人天然淋巴细胞从造血干祖细胞向各谱系发育的关键阶段和调节机制，相关成果发表在Immunity，Cell Research上，并受邀在Trends In Immunology 总结和评述近期国际上T细胞发育研究进展。(2) 在免疫系统功能评价方面，深入解析了调控免疫细胞功能信号通路和蛋白质翻译后修饰，相关成果发表在Nature，Journal of Experiential Medicine，Cell Research, Cellular & Molecular Immunology等上。

1. Luoqian J, Yang W, Ding X, Tuo QZ, Xiang Z, Zheng Z, Guo YJ, Li L, Guan P, Ayton S, Dong B, Zhang H, Hu H*, Lei P*. Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis. Cellular & molecular immunology 2022 Aug;19(8):913-924.

2. Liu C, Gong Y, Zhang H, Yang H, Zeng Y, Bian Z, Xin Q, Bai Z, Zhang M, He J, Yan J, Zhou J, Li Z, Ni Y, Wen A*, Lan Y*, Hu H*, Liu B*.Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Research 2021 Oct;31(10):1106-1122.

3. Deng Y, Chen H, Zeng Y, Wang K, Zhang H*, Hu H*. Leaving no one behind: tracing every human thymocyte by single-cell RNA-sequencing. Seminars in immunopathology 2021 Feb;43(1):29-43.

4. Liu C, Lan Y, Liu B, Zhang H*, Hu H*. T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing. Trends in immunology 2021 Feb;42(2):165-175.

5. Yu H, Lin L, Zhang Z, Zhang H*, Hu H*. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal transduction and targeted therapy 2020 Sep 21;5(1):209.

6. Yang W, Chen X, Hu H*. CD4⁺ T-Cell Differentiation In Vitro. Methods in molecular biology 2020;2111:91-99.

7. Yang W, Gu Z, Zhang H*, Hu H*. To TRIM the Immunity: From Innate to Adaptive Immunity. Frontiers in immunology 2020 Oct 8;11:02157.

8. Zeng Y, Liu C, Gong Y, Bai Z, Hou S, He J, Bian Z, Li Z, Ni Y, Yan J, Huang T, Shi H, Ma C, Chen X, Wang J, Bian L, Lan Y*, Liu B*, Hu H*. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity 2019 Nov 19;51(5):930-948.e6.

9. Lin L, Hu X, Zhang H*, Hu H*. Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy. Frontiers in immunology 2019 Jun 20;10:1398.

10. Bai Y, Tong Y, Liu Y, Hu H*. Self-dsDNA in the pathogenesis of systemic lupus erythematosus. Clinical and experimental immunology 2018 Jan;191(1):1-10.

11. Li Q, Lin L, Tong Y, Liu Y, Mou J, Wang X, Wang X, Gong Y, Zhao Y, Liu Y, Zhong B, Dai L, Wei YQ, Zhang H*, Hu H*. TRIM29 negatively controls antiviral immune response through targeting STING for degradation. Cell discovery 2018 Mar 20;4:13.

12. Hu H, Sun SC*. Ubiquitin signaling in immune responses. Cell Research 2016 Apr;26(4):457-83.

13. Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC*. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. The Journal of experimental medicine 2016 Mar 7;213(3):399-414.

14. Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC*. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. The Journal of experimental medicine 2016 Mar 7;213(3):399-414.

15. Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC*. Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. Immunity 2014 Mar 20;40(3):342-54.

16. Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS*. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nature communications 2014 Dec 15;5:5798.

17. Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC*. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. The Journal of experimental medicine 2014 Jan 13;211(1):137-51.

18. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC*. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature 2013 Feb 21;494(7437):371-4.

19. Hu H, Wu X, Jin W, Chang M, Cheng X, Sun SC*. Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proceedings of the National Academy of Sciences of the United States of America 2011 Aug 2;108(31):12827-32.

20. Xu C, Zhang H, Hu H, He H, Wang Z, Xu Y, Chen H, Cao W, Zhang S, Cui L, Ba D, He W*. Gammadelta T cells recognize tumor cells via CDR3delta region. Molecular immunology 2007 Jan;44(4):302-10.

21. Hu H, Li L, Kao RY, Kou B, Wang Z, Zhang L, Zhang H, Hao Z, Tsui WH, Ni A, Cui L, Fan B, Guo F, Rao S, Jiang C, Li Q, Sun M, He W*, Liu G*. Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library. Journal of combinatorial chemistry 2005 Sep-Oct;7(5):648-56.